Abstract
The influence of stimulation dopaminergic D1 i D2 receptors in lateral geniculate body by flash visual evoked potentials (FVEP) in rats
- Z Katedry i Oddziału Klinicznego Okulistyki w Bytomiu Śląskiej Akademii Medycznej w Katowicach
- Z Katedry i Zakładu Farmakologii w Zabrzu-Rokitnicy Śląskiej Akademii Medycznej w Katowicach
Purpose
The topic of this paper is to define the influence of stimulation dopaminergic D1 i D2 receptors in lateral geniculate body by flash visual evoked potentials (FVEP).
Material and methods
Wistar rats were examined. There were stereotaxically implanted with guide caniula into the lateral geniculate body to inject substances and with VEPs electrodes on the skull and on the surface of visual cortex. VEPs curve before and after injection into the lateral geniculate body: 0.9% NaCl, agonists of dopamine receptors D1 – SKF 38393, and D2 Quinpirole and also the same agonist after antagonists D1 – SCH 23390, i D2 Sulpiride were analyzed.
Results
Stimulating receptors D1 in the lateral geniculate body cause amplitude increase and shortness of latency. Quinpirole, agonist of D2 receptor do not significant change FVEPs curve.
Conclusions
Stimulation of D1 receptors in the lateral geniculate body can improve visual transmission throught it and response in the occipital cortex.
Keywords
visual evoked potentials, lateral geniculate body, dopamine,rats
Integrated with
