Abstract
The evaluation of the expression of intercellulare adhesion molecule (ICAM-1) by conjunctival epithelial cells of patients with cystic fibrosis
- Z Kliniki Okulistyki Dziecięcej Akademii Medycznej w Białymstoku
- Z Zakładu Pediatrycznej Diagnostyki Laboratoryjnej Akademii Medycznej w Białymstoku
- Z III Kliniki Chorób Dzieci Akademii Medycznej w Białymstoku
Purpose
To investigate the expression of intercellulare adhesion molecule (ICAM-1) by conjunctival epithelial cells of patients with cystic fibrosis
Material and methods
15 patients with cystic fibrosis and 15 control subjects were included in this study. Impression cytology specimens were collected and analyzed by flow cytometry and analyzed by flow cytometry.
Results
A significant increase of ICAM-1 expression by epithelial cells was found in patients with cystic fibrosis compared with normal eyes.
Conclusions
Increase of ICAM-1 expression by epithelial cells in cystic fibrosis patients suggests, that the inflammation appears to have a role in the pathogenesis of the ocular surface changes and may be a marker of the inflammatory status in cystic fibrosis.
Keywords
ICAM-1, cystic fibrosis, impression cytology, flow cytometry
Integrated with
