Abstract
The analysis of I125 brachytherapy complications in cases of uveal melanoma
- Katedra i Klinika Okulistyki Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie
Introduction
Analysis of type and frequency of complications after brachytherapy I125 between 1–12 months after treatment and during the following controls.
Material and methods
147 persons (76 men and 71 women) aged 23–86 years (mean 57 years), were treated in our clinic in 1998–2001. In 43% of the cases the thickness of the tumor was more than 8 mm and in 94% the maximum diameter was bigger than 8.1 mm. The irradiation dose was 80–120 Gy, mean 100 Gy.
Results
Regression and stabilization of the tumor was achieved in 84,3% of all cases. Complications of different type and intensity associated with brachytherapy I125 were observed in majority of the cases. The complications observed were: radiation retinopathy (52%), radiation maculopathy (33,6%), radiation optic neuropathy (25,3%), vitreous hemorrhage (8,8%), glaucoma (20,5%) and cataract (18,5%).
Conclusions
125I brachytherapy yields good results in cases of uveal melanoma, however it’s associated with post radiation complications.
Keywords
choroidal melanoma, uveal melanoma, brachytherapy I125, radiation retinopathy, radiation maculopathy, radiation optic neuropathy, consecutive glaucoma and cataract
Integrated with
