Abstract
4/2009
vol. 111
Review paper
Pathogenesis of posterior capsule opacification in pseudophakia
- Klinikia Chorób Oczu Collegium Medicum w Bydgoszczy Uniwersytetu Mikołaja Kopernika w Toruniu
Klinika Oczna 2009, 111 (4): 369-374
Online publish date: 2009/12/19
The lens epithelial cells of A and E type are involved in pathogenesis of posterior capsule opacification (PCO). They undergo metaplasia into microfibroblasts, then migrate towards posterior capsule where they proliferate and form opacification. These processes are stimulated by cytokines and interleukines. The extracellular matrix which constitutes a scaffold for migration and attachment of epithelial cells plays an important role in PCO formation. Integrines intercede in this process.
Keywords
posterior capsule opacification, lens epithelial cells, extracellular matrix, cytokines, interleukines, integrines
Integrated with
