The pathology of the liver is associated with many disorders including the eye. We described ocular changes following hepatitis C. The most common ophthalmic findings in hepatitis C patients treated with interferon-α involve keratoconjunctivitis, scleritis, dry eye syndrome, uveitis, retinopathy, retinal hemorrhages, anterior ischemic optic neuropathy, retinal vascular changes and macular oedema, as well as electroretinogram, visual field and OCT abnormalities.