Abstract
2/2007
vol. 109
Original paper
The assessment of the correlation between vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF-α), interleukin 6 (IL-6), glycaemic control (HbA1c) and the development of the diabetic retinopathy in children with diabetes mellitus type 1
- Klinika Pediatrii, Hematologii, Onkologii i Endokrynologii Akademii Medycznej w Gdańsku
- Zakład Immunologii Akademii Medycznej w Gdańsku
- Katedra i Klinika Chorób Oczu Akademii Medycznej w Gdańsku
Klinika Oczna 2007, 109 (2): 150-154
Online publish date: 2007/06/12
The aim of the work is to assess the correlation between HbA1c, VEGF, TNF-α, IL-6 and the development of diabetic retinopathy in children diagnosed with diabetes mellitus type 1. One hundred fourty nine children with long-standing diabetes mellitus type 1 were enrolled in the study. The patients were divided into two subgroups: children with retinopathy (Group 1; n=28) and children without retinopathy (Group 2, n=121). The control group consisted of 62 healthy children. All the examined children had VEGF, TNF-α and IL-6 measured in the blood serum using highly sensitive ELISA tests. Statistically significant higher blood serum levels of HbA1c, VEGF, TNF-α and IL-6 were found in the group 1 in comparison with the group 2. Children of the group 2 in relation to healthy controls showed statistically significant higher blood serum levels of VEGF, TNF-α and IL-6. Elevated levels of VEGF, TNF-α, IL-6, HbA1c in blood serum of children with diabetes mellitus type 1 detected before development of overt signs of diabetic retinopathy might indicate the possibility of the occurrence of changes in the eye shortly.
Keywords
Diabetes Mellitus type 1, retinopathy diabetica, VEGF, TNF-α, IL-6
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