Abstract
Estimation of immunological markers in children with intermediate uveitis symptoms
- Z Katedry i Kliniki Okulistycznej Akademii Medycznej we Wrocławiu
- Z Katedry Propedeutyki Pediatrii i Kliniki Immunologii i Reumatologii Wieku Dziecięcego Akademii Medycznej we Wrocławiu
Purpose
The purpose of this study was to estimate markers of immunological response in the blood of children with intermediate uveitis
Material and methods
: The records of 13 children (26 eyes), aged 10-17 years, with idiopathic intermediate uveitis were reviewed. In all cases indicators of inflammation and immunological response parameters were analyzed during the active stage of the disease.
Results
: In almost all patients ((90%) with intermediate uveitis disturbances in the level and activity of lymphocyte system, were detected. There were also nonspecific changes in immunoglobulins level in all patients, in 31% in more then one class of immunoglobulins. Chemiluminescence of phagocytic cells were reduced in more than 50% of children, and increase in their phagocytic activity was observed in 62% of patients. Circulating immune complexes were present in 50% of cases.
Conclusions
The study presents data supporting the theory of autoimmunological background of the intermediate uveitis.
Keywords
intermediate uveitis, cystoid macular oedema, retinal vasculitis, immune system, lymphocytes, pathogenesis
Integrated with
