Abstract
The estimation of selected parameters in antioxidant system in red blood cells in ROP screening of premature infants
- Z Kliniki Okulistyki Dziecięcej Akademii Medycznej w Białymstoku
- Z Kliniki Neonatologii Akademii Medycznej w Białymstoku
- Z Zakładu Chemii Analitycznej i Nieorganicznej Akademii Medycznej w Białymstoku
Purpose
To estimate correlation between concentration of antioxidant system parameters in red blood cells in premature infants and prevalence of ROP
Material and methods
We examined 16 premature infants with the average birth weight of 1071g and gestational age of 29.1 weeks. Supraoxide dismutase (SOD), reduced glutatione (GSH), and glutathione peroxidase (GSH-Px), were measured at day 1 (cord blood), 7-th and 14-th day after birth. Premature infants had ROP screening. The control group included 12 infants born at term.
Results
8 premature infants had ROP. There were higher levels of SOD, GSH and GSH-Px in premature infants with and without ROP, than in control group. Premature infants with ROP had lowest levels of GSH.
Conclusions
The glutathione status of red blood cells as a oxidative stress index in premature infants might be a reliable parameter, facilitating the early recognition of patients in immediate danger of ROP development.
Keywords
retinopathy of prematurity, antioxidants, oxidative stress
Integrated with
