Abstract
3/2021
vol. 123
Review paper
Mycotic corneal ulcers caused by Fusarium spp.- available therapeutic options
- Independent Public Clinical Ophthalmology Hospital in Warsaw, Poland
- Chair and Department of Ophthalmology, II Faculty of Medicine, Medical University of Warsaw, Poland
- Department of Microbiology of the Central Clinical Hospital, University Clinical Center of the Medical University of Warsaw, Poland
- Department of Dental Microbiology, Medical University of Warsaw, Poland
KLINIKA OCZNA 2021, 123, 3: 108–113
Online publish date: 2021/10/13
Fungal corneal ulcers caused by Fusarium spp. are known as sight threatening infection with bad course.
Fungus properties, diagnostic difficulties and limited therapeutic ways result in poor outcomes.
Three of antimycotic drugs are effective against Fusarium spp.: natamycin, amphotericin B and voriconazole. Natamycin is the only drug approved by FDA (Food and Drug Administration) for treatment of corneal ulcers caused by Fusarium spp.
Fungistatic work and limited ocular penetration of antimycotic drugs lead to therapeutic keratoplasty in cases with extremely bad course. Patient with recurrent infections and very advanced inflammation, require enucleation.
Fungus properties, diagnostic difficulties and limited therapeutic ways result in poor outcomes.
Three of antimycotic drugs are effective against Fusarium spp.: natamycin, amphotericin B and voriconazole. Natamycin is the only drug approved by FDA (Food and Drug Administration) for treatment of corneal ulcers caused by Fusarium spp.
Fungistatic work and limited ocular penetration of antimycotic drugs lead to therapeutic keratoplasty in cases with extremely bad course. Patient with recurrent infections and very advanced inflammation, require enucleation.
Keywords
corneal ulcer, Fusarium spp, natamycin, voriconazole, therapeutic penetrating keratoplasty
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