Abstract
2/2005
vol. 107
Original paper
IFN-γ in tear fluid in patients with cystic fibrosis
- Klinika Okulistyki Dziecięcej Akademii Medycznej w Białymstoku
- Zakład Laboratoryjnej Diagnostyki Pediatrycznej Akademii Medycznej w Białymstoku
- III Klinika Chorób Dzieci Akademii Medycznej w Białymstoku
Klinika Oczna 2005, 107(4-6): 287-288
Online publish date: 2005/07/02
Introduction
To evaluate IFN-γ concentration in tear fluid in CF patients.
Material and methods
Tear samples were collected from 15 CF patients at the age 10-21, and from 15 patients in control group at the age 11-20. Cytokine levels were determined by ELISA.
Results
The concentration of IFN-γ in tear fluid in CF patients was 10.75±2.23 pg/ml, and 4.06±0.57 pg/ml in control group.
Conclusions
The results of this study indicate that increased concentration of IFN-γ in the tear fluid may be an important factor in the pathogenesis of dry eye in CF patients. They also open new perspectives related to therapeutic management.
Keywords
cystic fibrosis, interferon-gamma
Integrated with
