Concentration of interleukine-8 
in tears in patients with cystic fibrosis

Małgorzata Mrugacz; Beata Żelazowska; Alina Bakunowicz-Łazarczyk; Alina Minarowska; Jolanta Wysocka

Abstract

2/2006 vol. 108

Original paper

Concentration of interleukine-8 in tears in patients with cystic fibrosis

Małgorzata Mrugacz ¹

,

Beata Żelazowska ²

,

Alina Bakunowicz-Łazarczyk ¹

,

Alina Minarowska ³

,

Jolanta Wysocka ²

Z Kliniki Okulistyki Dziecięcej Akademii Medycznej w Białymstoku
Z Zakładu Laboratoryjnej Diagnostyki Pediatrycznej Akademii Medycznej w Białymstoku
Z III Kliniki Chorób Dzieci Akademii Medycznej w Białymstoku

Online publish date: 2006/06/25

View full text

AMA

Mrugacz M, Żelazowska B, Bakunowicz-Łazarczyk A, Minarowska A, Wysocka J. Concentration of interleukine-8 in tears in patients with cystic fibrosis. Klinika Oczna / Acta Ophthalmologica Polonica. 2006;108(2):184-185.

APA

Mrugacz, M., Żelazowska, B., Bakunowicz-Łazarczyk, A., Minarowska, A., & Wysocka, J. (2006). Concentration of interleukine-8 in tears in patients with cystic fibrosis. Klinika Oczna / Acta Ophthalmologica Polonica, 108(2), 184-185.

Chicago

Mrugacz, Małgorzata, Beata Żelazowska, Alina Bakunowicz-Łazarczyk, Alina Minarowska, and Jolanta Wysocka. 2006. "Concentration of interleukine-8 in tears in patients with cystic fibrosis". Klinika Oczna / Acta Ophthalmologica Polonica 108 (2): 184-185.

Harvard

Mrugacz, M., Żelazowska, B., Bakunowicz-Łazarczyk, A., Minarowska, A., and Wysocka, J. (2006). Concentration of interleukine-8 in tears in patients with cystic fibrosis. Klinika Oczna / Acta Ophthalmologica Polonica, 108(2), pp.184-185.

MLA

Mrugacz, Małgorzata et al. "Concentration of interleukine-8 in tears in patients with cystic fibrosis." Klinika Oczna / Acta Ophthalmologica Polonica, vol. 108, no. 2, 2006, pp. 184-185.

Vancouver

Mrugacz M, Żelazowska B, Bakunowicz-Łazarczyk A, Minarowska A, Wysocka J. Concentration of interleukine-8 in tears in patients with cystic fibrosis. Klinika Oczna / Acta Ophthalmologica Polonica. 2006;108(2):184-185.

Purpose

To evaluate IL-8 concentration in tears fluid in cystic fibrosis patients

Material and methods

Tears samples were collected from 18 CF Patients and 18 normal controls. Cytokine level was determined by ELISA.

Results

A significant increase of IL-8 concentration in tears fluid was found in CF patients compared with controls.

Conclusions

Increase IL-8 concentration in tears fluid in CF patients suggests a role of immunologic processes in the pathogenesis of the ocular changes, and may be a marker of the inflammatory status in ocular surface in cystic fibrosis.

Keywords

cystic fibrosis, tears, interleukin-8