Abstract
4/2010
vol. 112
Original paper
Concentration assessment of interleukin 8 in serum at children with uveitis
- Z Zakładu Laboratoryjnej Diagnostyki Pediatrycznej Uniwersytetu Medycznego w Białymstoku
- Z Kliniki Okulistyki Dziecięcej Uniwersytetu Medycznego w Białymstoku
Online publish date: 2010/12/22
Purpose: Uveitis in children is a visual threatening disease with a complication rate of more than 75%. At the children the
uveitis differs in several aspect from adults like: clinical presentation or complication of disease. The etiology of uveitis is still
unknown, but T lymphocytes are generally key mediators of the pathogenesis of uveitis.
In our study we evaluate IL-8 concentration in serum in uveitis patients.
Material and methods: Serum sample were collected from 28 uveitis patients and 20 people from control group. The level of
IL-8 was measured with specific enzyme- linked immunoassays ELISA methods (R & D Systems).
Results: Level of IL-8 in uveitis group was a significant higher (p<0.04) compared with control group.
Conclusions: Increased levels of interleukin 8 in serum of children with uveitis may suggest innate immune mechanisms in the
acute disease.
uveitis differs in several aspect from adults like: clinical presentation or complication of disease. The etiology of uveitis is still
unknown, but T lymphocytes are generally key mediators of the pathogenesis of uveitis.
In our study we evaluate IL-8 concentration in serum in uveitis patients.
Material and methods: Serum sample were collected from 28 uveitis patients and 20 people from control group. The level of
IL-8 was measured with specific enzyme- linked immunoassays ELISA methods (R & D Systems).
Results: Level of IL-8 in uveitis group was a significant higher (p<0.04) compared with control group.
Conclusions: Increased levels of interleukin 8 in serum of children with uveitis may suggest innate immune mechanisms in the
acute disease.
Integrated with
