Abstract
2/2010
vol. 112
Review article
Safety of ranibizumab therapy in wet AMD and the role of vascular endothelial growth factors in physiological angiogenesis
- Department of Ophthalmology, Military Medical Institute in Warsaw
Online publish date: 2010/07/21
Vascular endothelial growth factor – A (VEGF-A), is a major factor implicated in choroidal neovascularisation (CNV) and therefore
a target for therapeutic agents in wet age related macular degeneration (AMD). Ranibiuzumab (Lucentis) blocks all active isoforms
of VEGF-A and the products of their degradation. It penetrates through all layers of the retina in order to reach the target tissue.
It is quickly removed from the system and it is characterised by low level of immunogenicity. The essence of angiogenesis is formation of new vessels by branching and expansion of already existing ones. Angiogenesis is an important physiological process
that takes place during the healing of wounds, reconstruction of hypoxic injury and reproduction. However some diseases such as
cancer, arthritis, diabetes and neovascular AMD are associated with persistent unregulated angiogenesis. There is an important
question whether binding vascular-endothelial growth factors in wet AMD therapies using ranibizumab is correlated with the increase of the incidence of systematic adverse effects (AEs), such as cardiovascular episodes or thrombosis.
The aim of this article is to present ranibizumab as a safe drug in treating wet AMD patients. Even though the concentration of
Lucentis administered in a dose of 0.3 or 0.5 mg into the vitreous body in the organism is very low, the incidence of AEs during the
anti-VEGF therapy was traced. In MARINA and ANCHOR studies, occurrence of possible AEs was observed. No statistically significant differences were shown in the AEs frequency between the patients treated with ranibizumab and the control group, and in
correlation with the general population of patients suffering from wet AMD.
a target for therapeutic agents in wet age related macular degeneration (AMD). Ranibiuzumab (Lucentis) blocks all active isoforms
of VEGF-A and the products of their degradation. It penetrates through all layers of the retina in order to reach the target tissue.
It is quickly removed from the system and it is characterised by low level of immunogenicity. The essence of angiogenesis is formation of new vessels by branching and expansion of already existing ones. Angiogenesis is an important physiological process
that takes place during the healing of wounds, reconstruction of hypoxic injury and reproduction. However some diseases such as
cancer, arthritis, diabetes and neovascular AMD are associated with persistent unregulated angiogenesis. There is an important
question whether binding vascular-endothelial growth factors in wet AMD therapies using ranibizumab is correlated with the increase of the incidence of systematic adverse effects (AEs), such as cardiovascular episodes or thrombosis.
The aim of this article is to present ranibizumab as a safe drug in treating wet AMD patients. Even though the concentration of
Lucentis administered in a dose of 0.3 or 0.5 mg into the vitreous body in the organism is very low, the incidence of AEs during the
anti-VEGF therapy was traced. In MARINA and ANCHOR studies, occurrence of possible AEs was observed. No statistically significant differences were shown in the AEs frequency between the patients treated with ranibizumab and the control group, and in
correlation with the general population of patients suffering from wet AMD.
Keywords
ranibizumab, wet AMD, pathogenesis, vascular endothelial growth factors, safety
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