Ocena stężenia interleukiny 8 w surowicy krwi u dzieci z zapaleniem błony naczyniowej

Purpose: Uveitis in children is a visual threatening disease with a complication rate of more than 75%. At the children the

uveitis differs in several aspect from adults like: clinical presentation or complication of disease. The etiology of uveitis is still

unknown, but T lymphocytes are generally key mediators of the pathogenesis of uveitis.

In our study we evaluate IL-8 concentration in serum in uveitis patients.

Material and methods: Serum sample were collected from 28 uveitis patients and 20 people from control group. The level of

IL-8 was measured with specific enzyme- linked immunoassays ELISA methods (R & D Systems).

Results: Level of IL-8 in uveitis group was a significant higher (p<0.04) compared with control group.

Conclusions: Increased levels of interleukin 8 in serum of children with uveitis may suggest innate immune mechanisms in the

acute disease.