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eISSN: 2719-3209
ISSN: 0023-2157
Klinika Oczna / Acta Ophthalmologica Polonica
Bieżący numer Archiwum Filmy Artykuły w druku O czasopiśmie Suplementy Rada naukowa Bazy indeksacyjne Prenumerata Kontakt Zasady publikacji prac Standardy etyczne i procedury
 
1/2022
vol. 124
 
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Artykuł oryginalny

Evaluation of efficacy of indocyanine green enhanced transpupillary thermotherapy as a single treatment for recurrence of intraocular retinoblastoma

Krzysztof Cieślik
1
,
Anna Rogowska
1
,
Małgorzata Danowska
1
,
Karolina Trocka
1
,
Olga Rutynowska
2
,
Bożenna Dembowska-Bagińska
2
,
Wojciech Hautz
1

1.
Department of Ophthalmology, Children’s Memorial Health Institute in Warsaw, Poland
2.
Department of Oncology of the Children’s Memorial Health Institute in Warsaw, Poland
KLINIKA OCZNA 2022, 124, 1: 30–34
Data publikacji online: 2022/01/05
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Aim of the study
Evaluation of efficacy of indocyanine green enhanced transpupillary thermotherapy (ICG-TTT) as a single treatment for recurrence of retinoblastoma.

Material and methods
Single-center, retrospective study of 18 procedures in 11 eyes of 11 retinoblastoma patients (12 tumors), with a mean follow-up of 31.94 months (range 1-44 months). Nine tumors had one procedure of ICG-TTT and 3 tumors had more than one procedure due to relapses. The technique involved applying thermotherapy (TTT) via an indirect ophthalmoscope 30 seconds after intravenous indocyanine administration at a dose of 0.6 mg/kg.

Results
During follow-up, tumor recurrence after ICG-TTT developed after 11 procedures. Taking into account cases where ICG-TTT was the only treatment for retinoblastoma relapse, the success rate was 26.7% (4 effective procedures out of 15). Overall, tumor control and globe salvage was achieved in all eyes with ICG-TTT alone or with other forms of therapy, e.g. systemic chemotherapy, ophthalmic artery chemosurgery, brachytherapy.

Conclusions
ICG-TTT as the only procedure for relapses of retinoblastoma has a moderate success rate. No ocular or systemic complications were noted.

słowa kluczowe:

retinoblastoma, indocyanine, treatment, thermotherapy, laser

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