en POLSKI
eISSN: 2719-3209
ISSN: 0023-2157
Klinika Oczna / Acta Ophthalmologica Polonica
Current issue Archive Videos Articles in press About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
4/2018
vol. 120
 
Share:
Share:
more
 
 
abstract:
Original paper

Structural retinal changes in optical coherence tomography in patients with multiple sclerosis patients

Karolina Krix-Jachym
1
,
Joanna Wierzbowska
1
,
Izabela Jamiołkowska
1
,
Izabela Skrzypiec
1
,
Marek Rękas
1

1.
Klinika Okulistyki Wojskowego Instytutu Medycznego w Warszawie
Online publish date: 2019/02/27
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Purpose
To demonstrate morphological changes in peripapillary retinal nerve fibre layer thickness and peripapillary retinal ganglion cell complex in patients with multiple sclerosis.

Material and methods
73 eyes of 37 patients were enrolled: 34 eyes of 17 patients with multiple sclerosis and 39 eyes of 20 healthy individuals as a control group. The study group was further subdivided into two groups according to the presence/ absence of optic neuritis in medical history. All patients underwent an ophthalmic examination including visual acuity, fundus biomicroscopy as well as optical coherence tomography assessment of peripapillary retinal nerve fibre layer thickness and peripapillary ganglion cell complex thickness.

Results
The peripapillary retinal nerve fibre layer thickness was reduced in subjects as compared to controls (87.21± 12.1 vs. 107.23 ± 10.31 μm, p<.001) and the reduction was greater in eyes with optic neuritis (79.65 ± 10.95 vs. 91.89 ± 10.48 vs. 107.23 ± 10.32, p = .002691). Similarly, the ganglion cell complex thickness was reduced in subjects as compared to controls (127.04 ± 13.85 vs. 150.67 ± 12.40 μm, p = .00093) and the reduction was greater in eyes with optic neuritis (117.85 ± 12.85 vs. 132.74 ±11.34, p<.001). There was a strong correlation between the peripapillary nerve fibre layer and ganglion cell complex thickness.

Conclusions
The peripapillary retinal nerve fibre layer thickness and the ganglion cell complex were reduced in patients with multiple sclerosis. Although the reduction was also confirmed in patients without a history of optic neuritis, it was significantly larger in patients with a history of optic neuritis. Optical coherence tomography can aide the diagnosis and monitoring of patients with multiple sclerosis.

keywords:

ganglion cell complex (GCC), retinal nerve fiber layer (RNFL), multiple sclerosis (MS), optic neuritis (ON), Optical Coherence Tomography (OCT)

Quick links
© 2021 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.