Role of complement system in the pathogenesis of AMD

Anna Machalińska; Danuta Karczewicz

eISSN: 2719-3209
ISSN: 0023-2157

Klinika Oczna / Acta Ophthalmologica Polonica

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4/2009
vol. 111

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abstract:

Review paper

Role of complement system in the pathogenesis of AMD

Anna Machalińska

^{1, 2}

,

Danuta Karczewicz

³

Katedra i Zakład Histologii i Embriologii Pomorskiej Akademii Medycznej w Szczecinie
Katedra i Zakład Patologii Ogólnej Pomorskiej Akademii Medycznej w Szczecinie
Katedra i Klinika Okulistyki Pomorskiej Akademii Medycznej w Szczecinie

Klinika Oczna 2009, 111 (4): 384-387

Online publish date: 2009/12/19

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Age related macular degeneration (AMD), is the leading cause of blindness in individuals over age 50 years old. The pathogenesis of AMD is still not well understood with both genetic and environmental factors known to influence susceptibility to this condition. Data accumulated in the last decade implicate the chronic inflammatory processes as playing an important role in the progression of AMD. According to the recent findings, complement system is suggested to be a triggering point of the initiation of pathologic inflammatory response in the development and clinical course of AMD.

keywords:

Role of complement system in the pathogenesis of AMD

Anna Machalińska 1, 2 , Danuta Karczewicz 3

age-related macular degeneration, complement system, arteriosclerosis

Anna Machalińska

^{1, 2}

,

Danuta Karczewicz

³