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4/2009
vol. 111 abstract:
Original paper
Evaluation of VEGF and IGF-1 plasma levels in preterm infants – potential correlation with retinopathy of prematurity, clinical implications
Anna Machalińska
1, 2
,
Monika Modrzejewska
3
,
Violetta Dziedziejko
2
,
Maciej Kotowski
2
,
Krzysztof Safranow
2
,
Aleksandra Herbowska
2
,
Danuta Karczewicz
3
Klinika Oczna 2009, 111 (4): 302-306
Online publish date: 2009/12/19
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Introduction
Purpose: Insulin-like growth factor-1 plays an important role in fetal growth and development, and its level increases with gestational age. The latest reports show that IGF-1 can directly influence the production of VEGF and regulate the development of blood vessels. Thus, the aim of the study was to evaluate the plasma concentrations of IGF-1 and VEGF as well as analyze their mutual correlation in preterm infants with retinopathy of prematurity (ROP), compared with preterm infants without ROP and full-term babies. Material and methods To address this issue, peripheral blood samples (PB) were analyzed and collected 10 weeks after delivery from: 25 preterm infants with proliferative stage of retinopathy of prematurity (ROP) and neovascularization (stage 3 or more advanced), 25 preterm infants without ROP, and 25 healthy full-term control infants. Plasma concentrations of VEGF and IGF-1 were measured using high-sensitivity enzyme-linked immunosorbent assay (ELISA) kits. Results Increased concentrations of VEGF (p<0.05), were found in the PB of the preterm infants with ROP compared with the preterm babies without retinopathy as well as with the full-term control infants, in whom the lowest levels of the growth factor were observed. The plasma concentrations of IGF-1 in the preterm infants were significantly lower than those of the full-term babies (p<0.001). After adjustment for gestational age as a independent variable, a tendency to higher concentrations of IGF-1 was observed in the preterm infants with ROP. Conclusions Disturbances in the interactions of VEGF and IGF-1 at early stages of ROP, leading to uncontrolled increases in their levels in the proliferative phase of disease, can play an important role in the pathogenesis of retinopathy of prematurity. keywords:
VEGF, IGF-1, retinopathy of prematurity, retinal neovascularization |
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POLSKI
