|
Current issue
Archive
Videos
Articles in press
About the journal
Supplements
Editorial board
Reviewers
Abstracting and indexing
Subscription
Contact
Instructions for authors
Ethical standards and procedures
Editorial System
Submit your Manuscript
|
3/2011
vol. 113 abstract:
Original paper
Elevated level of circulating endothelial cells as an exponent of chronic vascular dysfunction in the course of AMD
Anna Machalińska
1, 2
,
Krzysztof Safranow
3
,
Zofia Sylwestrzak
2
,
Krzysztof Szmatłoch
2
,
Leszek Kuprjanowicz
2
,
Danuta Karczewicz
2
Klinika Oczna 2011, 113 (3): 228-232
Online publish date: 2011/10/01
View
full text
Get citation
ENW EndNote
BIB JabRef, Mendeley
RIS Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
Introduction
Purpose: In recent years, emerging data support the concept of endothelial dysfunction in the course of age-related macular degeneration (AMD). Circulating endothelial cells (CECs) are desquamated mature cells that have detached from the intimal monolayer in response to endothelial injury. In this study we sought to explore the potential role of endothelial dysfunction in pathogenesis of AMD by measuring the concentration of CECs in peripheral blood of AMD patients. Material and methods Peripheral blood samples from 31 patients with diagnosed dry AMD and 46 patients with neovascular AMD were collected. Forty six, age- and sex-matched volunteers without AMD were enrolled as a control group. CECs were counted and analyzed by flow cytometry. Results Multivariate analyses of patients and controls adjusted for age, gender, presence of ischemic heart disease, hypertension and smoking (current or past) revealed that both wet (ß = +0.45, p = 0.0003) and dry (ß = +0.28, p = 0.027) forms of AMD are independent factors associated with higher number of CECs. Conclusions Our results suggest that there is an endothelial alteration accompanying AMD. Increased numbers of CECs AMD patients reflect a severe vascular disturbance and may contribute to the disease process. These findings can help expand our knowledge of the pathogenic mechanisms of AMD and may be relevant to the potential treatment of this disease. keywords:
Age-related macular degeneration, endothelial cells, blood vessels |
|
POLSKI
