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4/2010
vol. 112 abstract:
Original paper
Concentration assessment of interleukin 8 in serum at children with uveitis
Beata Żelazowska-Rutkowska
1
,
Małgorzata Mrugacz
2
,
Jolanta Wysocka
1
,
Alina Bakunowicz-Łazarczyk
2
Online publish date: 2010/12/22
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Purpose: Uveitis in children is a visual threatening disease with a complication rate of more than 75%. At the children the
uveitis differs in several aspect from adults like: clinical presentation or complication of disease. The etiology of uveitis is still unknown, but T lymphocytes are generally key mediators of the pathogenesis of uveitis. In our study we evaluate IL-8 concentration in serum in uveitis patients. Material and methods: Serum sample were collected from 28 uveitis patients and 20 people from control group. The level of IL-8 was measured with specific enzyme- linked immunoassays ELISA methods (R & D Systems). Results: Level of IL-8 in uveitis group was a significant higher (p<0.04) compared with control group. Conclusions: Increased levels of interleukin 8 in serum of children with uveitis may suggest innate immune mechanisms in the acute disease. |
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POLSKI
